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Chromosome Structure Alterations Webinar

Chromosome Structure Alterations in Pediatric and Adult Cancers Webinar
Hosted by The Brain Tumour Charity
Thursday, April 22 2021 at 3:00 pm BST/ 10:00 am EST
Register Today

Doctors Beroukhim and Nazarian present their work on how chromatin modifications and aneuploidy are involved in DIPG and the wider implications in other cancers.

Alterations in chromosome structure, both at the chromatin level and in the form of aneuploidy, are a central feature of cancers in general and DIPG specifically. In this webinar, we will discuss two projects that look at different aspects of these changes. Mutations in histone encoding genes were initially discovered in DIPG; Dr. Nazarian will discuss data that extend these findings to other related proteins and cancers and their implications for chromatin and genomic stability. Dr. Beroukhim will then discuss the implications of the genomic instability that results, describing methods to determine the selective pressures that shape large-scale aneuploidies across cancers.

Overview of the webinar
- Novel mutations across histone genes may contribute to tumorigenicity across many cancers
- Chromosome arm-level copy-number alterations are among the most frequent alterations in cancer
- Mutations affecting histone encoding genes affect nucleosome instability by altering evolutionarily conserved protein regions
- Q&A
- Join the speaker of your choice for a 15-minute open discussion on a selected topic (topic TBC):
- Breakout Room 1 - with Dr Beroukhim
- Breakout Room 2 - with Dr Nazarian


- Dr Javad Nazarian, Head of DMG Research Center at University Children’s Hospital, Zurich Switzerland, and an Associate Professor of Pediatrics at the George Washington University and Children’s National Medical Center in Washington, D.C.
- Dr Rameen Beroukhim, Associate Professor of Medicine, Harvard Medical School and Associate Member, Broad Institute. Divisions of Medical Oncology and Cancer Biology, Dana-Farber Cancer Institute

Learn more and register today:

4/22/2021 9:00 AM - 10:15 AM